Interleukin

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers. For some detailed interleukins see Interleukin-10 and Interleukin-15.

IL-1 α
2ila - hIL-1 α - human 2kki - hIL-1 α residues 121-271  2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR

IL-1 β
2wry - cIL-1 β – chicken 3nj5 – cIL-1 β (mutant)  2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β 1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)  6i1b, 7i1b - hIL-1 β - NMR 3ltq - hIL-1 β residues 117-269  3pok - hIL-1 β residues 117-269 (mutant)  1itb - hIL-1 β + IL-1 receptor 1 extracellular domain 3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein 2kh2 - hIL-1 β + SCFV - NMR 1md6 – mIL-1F5 – mouse 2mib, 8i1b - mIL-1 β

IL-2
1m47, 1m4c, 3ink – hIL-2 1irl – hIL-2 (mutant) - NMR 2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ 1z92 - hIL-2 + IL-2 receptor α<BR /> 1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor<BR /> 1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor<BR />

IL-3
1jli – hIL-3 (mutant) – NMR<BR />

IL-4
2b8u, 1hik, 2int – hIL-4<BR /> 2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR<BR /> 2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant) <BR /> 1iar - hIL-4 + IL-4 receptor α (mutant) <BR /> 3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR /> 3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α

IL-5
1hul – hIL-5<BR /> 3b5k – mIL-5

IL-6
1alu – hIL-6<BR /> 1il6, 2il6 – hIL-6 - NMR<BR /> 1p9m - hIL-6 + IL-6 receptor α and β

IL-7
3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain

IL-8
3il8 – hIL-8<BR /> 1il8, 2il8 – hIL-8]- NMR<BR /> 1qe6, 1icw – hIL-8 (mutant) <BR /> 1ikl, 1ikm - hIL-8 (mutant) - NMR<BR /> 1ilp, 1ilq - hIL-8 + IL-8 receptor peptide

IL-10
2h24, 1inr, 2ilk, 1ilk – hIL-10<BR /> 1j7v – hIL-10 + IL-10 receptor α (mutant) <BR /> 1y6k - hIL-10 residues 19-178 + IL-10 receptor α

IL-10 viral
1vlk - hvIL-10 residues 26-170 - human herpesvirus 4<BR /> 1y6m - hvIL-10 residues 26-170 + IL-10 receptor α <BR /> 1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α <BR /> 1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR /> 1lk3 - hvIL-10 residues 26-175 + antibody

IL-12
1f45 - hIL-12 α and β (mutant) <BR /> 1f42 - hIL-12 β P40 domain<BR /> 3hmx - hIL-12 α and β+ antibody

IL-13
1ijz, 1ik0 – hIL-13 – NMR<BR /> 1ga3 - hIL-13 residues 21-132 - NMR<BR /> 3l5w, 3l5x, 3l5y, 3g6d - hIL-13 residues 35-146 + antibody<BR /> 3lb6 - hIL-13 + IL-13 receptor α2<BR /> 3bpo - hIL-13 + IL-4 receptor α + IL-13 receptor α

IL-15
2xqb – hIL-15 + antibody<BR /> 2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α

IL-16
1i16 – hIL-16 - NMR<BR /> 1x6d – hIL-16 PDZ domain – NMR<BR />

IL-17
2vxs - hIL-17A residues 20-255 + antibody<BR /> 1jpy – hIL-17F<BR /> 3jvf - hIL-17F + IL-17 receptor α

IL-18
1j0s – hIL-18 - NMR<BR /> 2vxt - hIL-18 (mutant) + antibody<BR /> 3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein

IL-19
1n1f – hIL-19

IL-21
2oqp– hIL-21 – NMR<BR />

IL-22
1ykb, 1m4r – hIL-22<BR /> 3g9v - hIL-22 residues 29-179 + IL-22 receptor α2<BR /> 3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1

IL-23
3d87 - hIL-23 α<BR /> 3d85 - hIL-23 α + antibody<BR /> 3duh - hIL-23 α + hIL-12 β

IL-33
2kll - hIL-33 residues 110-270 - NMR<BR />